analysis of diverse signal transduction pathways using the by Celine Moorman

By Celine Moorman

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EMBO J. 17: 5059– 5065. Kramer, J. , R. P. French, E. C. Park and J. J. Johnson, 1990 The Caenorhabditis elegans rol-6 gene, which interacts with the sqt-1 collagen gene to determine organismal morphology, encodes a collagen. Mol. Cell. Biol. 10: 2081–2089. Lackner, M. , S. J. Nurrish and J. M. Kaplan, 1999 Facilitation of synaptic transmission by EGL-30 Gq␣ and EGL-8 PLC␤: DAG binding to UNC-13 is required to stimulate acetylcholine release. Neuron 24: 335–346. , and S. Hekimi, 1998 The genetics of caloric restriction in Caenorhabditis elegans.

1995), whereas reduction of function of egl-30 results in decreased locomotion rates (Brundage et al. 1996). These G-protein pathways regulate diacylglycerol levels in an antagonistic manner (Lackner et al. 1999; Miller et al. 1999), either stimulating or inhibiting acetylcholine release through the diacylglycerol-binding protein, UNC-13. Our results show that there is yet another G-protein signaling cascade involved in locomotion: G␣s signals to the adenylyl cyclase SGS-1 to regulate locomotion.

A. FIELDS, D. D. MCKEE and P. J. CASEY, 2001 Interaction of Ga12 and Ga13 with the cytoplasmic domain of cadherin provides a mechanism for b-catenin release. Proc Natl Acad Sci U S A 98: 519-524. M ENDEL , J. , H. C. KORSWAGEN, K. S. LI U , Y. M. HAJDU -C RONIN , M. I. , 1995 Participation of the protein Go in multiple aspects of behavior in C. elegans. Science 267: 1652-1655. M ILLER, K. , A. ALFONSO , M. NGUYEN , J. A. CROWELL , C. D. , 1996 A genetic selection for Caenorhabditis elegans synaptic transmission mutants.

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