Animals with Novel Genes by Norman Maclean

By Norman Maclean

This ebook is set transgenic animals--animals into which new genes were artificially brought. It has chapters by means of top experts at the current state-of-play in regards to the software of the transgenic know-how to various animal teams. Scientists have carried out experiments on a good variety of animal varieties, starting from protozoan cells, via nematode worms and fruit flies to many better vertebrates, and this e-book offers an in-depth, updated, finished and authoritative account of the paintings with all such animal forms. The most likely effect of transgenic animals at the way forward for agriculture and drugs is particularly nice. those animals supply an unmatched experimental method for the research of gene law, genetic points of sickness, and gene treatment. one of many pursuits of the ebook is for this reason to set transgenic animals within the context in their current and destiny contributions to technology and drugs.

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1991). Germline transformation of Drosophila melanogaster by purified P element transposase. Nucl. Acids Res. 19, 6336. Kitsin, R. , Butlrick, R. , McNally, E. , Kaplan, M. L. & Leinwand, L. A. (1991). Hormonal modulation of a gene injected into rat heart in vivo. Proc. Natl. Acad. Sci. 88, 4138-42. McKnight, R. , Wall, R. J. & Hennighausen, L. (1992). Matrix-attachment regions can impart position-independent regulation of a tissue-specific gene in transgenic mice. Proc. Natl. Acad. Sci. 89, 6943-7.

References Argos, P. et al. (1986). The integrase family of site-specific recombinases. EMBO Jr. 5, 433-40. Brown, P. (1992). Gene therapy wins official blessing: Report on the Committee on the Ethics of Gene Therapy. New Scientist, January, 18. Bruggemann, E. P. (1993). Environmental safety issues for genetically modified animals. / . Anim. Sci. 71 (Suppl. 3), 47-50. Clark, A. , Bishop, J. , Prowse, C , Simons, J. , Whitelaw, C. B. A. & Wilmut, I. (1989). Expression of human anti-hemophilic factor IX in the milk of transgenic sheep.

Finally, the molecular mapping of a number of insect genomes other than Drosophila has now been initiated. Foremost among these is the programme which aims to map the genome of the mosquito Anopheles gambiae. A preliminary, low-resolution map for part of this genome has been generated using PCR-amplified, microdissected segments Transgenic insects 39 from polytene chromosomes as segment-specific probes and markers (Zheng et al. 1991). It is hoped that a complete molecular map will be generated which can then be correlated with the genetic map and the very detailed cytological map which is available for this insect.

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