By Robert E. Kass, Colleen E. Clancy
This booklet comprises the main up-to date info regarding mechanisms and remedy of cardiac arrhythmia. a number of the issues mentioned during this textual content replicate very lately undertaken learn instructions together with genetics of arrhythmias, cellphone signalling molecules as strength healing ambitions and trafficking to the membrane. those new techniques and implementations of anti-arrhythmic remedy derive from many a long time of study as defined within the first bankruptcy by way of extraordinary Professors Michael Rosen (Columbia collage) and Michiel Janse (University of Amsterdam). The textual content covers alterations in methods to treatment through the years, arrhythmias in a number of cardiac areas and over many scales, from gene to protein to phone to tissue to organ.
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Extra resources for Basis and Treatment of Cardiac Arrhythmias
B. Robinson so-called pacemaker current, I f , generated by the HCN gene family, best ﬁts these criteria. The biophysical and molecular characteristics of this current are reviewed, and progress to date in developing selective pharmacologic agents targeting I f and in using gene and cell-based therapies to modulate the current are reviewed. Keywords Sino-atrial node · Automaticity · Pacemaker · HCN · Arrhythmia · Pharmacologic selectivity 1 Introduction The sino-atrial (SA) node is the specialized region of the cardiac right atrium where the heartbeat originates.
In 1799, Caleb Parry quoted a letter from a good friend, Edward Jenner, the discoverer of smallpox vaccination. Jenner described an autopsy he had done History of Arrhythmias 29 on a patient with angina pectoris who had died suddenly: “... I was making a transverse section of the heart pretty near its base when my knife struck something so hard and gritty as to notch it. I well remember looking up to the ceiling, which was old and gritty, conceiving that some plaster had fallen down. But upon further scrutiny, the real cause appeared: the coronaries were becoming bony canals” (Parry 1799; see also Friedman and Friedland 1998).
J Physiol (Lond) 15:121–138 Prevost JL, Battelli F (1899) Sur quelques effets des décharges électriques sur le coeur des Mammifères. H. N. Wilson and Thomas Lewis. Johns Hopkins Med J 138:279–288 Purkinje JE (1845) Mikroskopisch-neurologische Beobachtungen. Arch Anat Physiol Med II/III:281–295 Rosen MR, Reder RF (1981) Does triggered activity have a role in the genesis of clinical arrhythmias? Ann Intern Med 94:794–801 38 M. J. Janse · M. R. Rosen Rosenbaum DS, Jalife J (2001) Optical mapping of cardiac excitation and arrhythmias.