Cardiac Fibrosis and Heart Failure: Cause or Effect? by Ian M.C. Dixon, Jeffrey T. Wigle

By Ian M.C. Dixon, Jeffrey T. Wigle

The specific biology of cardiac fibroblasts and comparable cells, corresponding to cardiac myofibroblasts and valvular interstitial cells, distinguish them from different fibroblastic cells, an idea that's basically starting to be generally preferred. additional, the average signs that stimulate and inhibit cardiac fibrosis inside of those cells are usually not good understood. This quantity compiles articles that tackle the molecular mechanisms that keep an eye on the synthesis and secretion of the cardiac ECM. The booklet showcases chapters that spotlight dialogue of function of remodeling progress issue β (TGFβ), a big fibrogenic cytokine and its downstream effectors SMAD in lots of cardiac illnesses. extra, the contributions spotlight details to debate endogenous inhibitors of cardiac fibrosis, in addition to advances in tissue engineering particular to matrix within the center. eventually, discussions of unifying mechanisms of matrix home improvement in valves and myocardium are presented.

The mechanisms concerned about the stimulation of cardiac fibrosis aren't totally understood. more often than not the marginal attenuation of cardiac fibrosis because of a given remedy is a useful side-effect associated with different fundamental results on different cells, specially cardiomyocytes. only a few medications or brokers are recognized to impact the functionality and disorder of cardiac fibroblasts and myofibroblasts by myself. The publication is helping to translate the knowledge accrued inside to permit us to change the process fibrogenic occasions which are usual of cardiac fibrosis, and thereby decrease their burden at the sufferer and on society itself.

Show description

Read Online or Download Cardiac Fibrosis and Heart Failure: Cause or Effect? PDF

Similar cardiovascular books

Cardiogenic Shock

* A accomplished resource of data at the administration of cardiogenic surprise * a part of the AHA medical sequence released along side the yankee middle organization * makes a speciality of high-interest and rising themes in heart problems certain to cardiologists and different healthcare services * a useful gizmo for investigating, comparing and treating probably the most very important lingering demanding situations in acute cardiovascular care

Cardiac Catheter Book: Diagnostic and Interventional Techniques

Now achieving a bigger viewers, [this booklet] serves as an exceptional total contribution to the speedily evolving box of interventional cardiology. -- Doody businesses, Inc. Loaded with guidance, methods, and professional suggestions to daily medical difficulties, this ebook is a needs to for all experts and trainees acting cardiac catheterizations.

Understanding Cardiac Electrophysiology: A Conceptually Guided Approach

Within the fast-paced international of scientific education, scholars are usually inundated with the what of electrophysiology with no the why. This new textual content is designed to inform the tale of electrophysiology in order that the likely disparate myriad observations of medical perform come into concentration as a cohesive and predictable entire.

Additional info for Cardiac Fibrosis and Heart Failure: Cause or Effect?

Example text

Frangogiannis beneficial effects are associated with attenuated cardiac fibrosis, [88], these agents have a wide range of additional actions on the myocardium. Thus, the relative role of their anti-fibrotic effects in improving clinical outcome remains unclear. Aldosterone antagonists also reduce adverse remodeling and decrease circulating levels of fibrosis-associated markers in patients with acute myocardial infarction [89]. However, because of the broad effects of aldosterone on all cell types implicated in cardiac remodeling, the relative significance of anti-fibrotic actions in mediating the observed clinical is unknown.

Blaser and C. A. Simmons Fig. 1 Aortic valve cusp anatomy. a Illustration of an aortic valve cusp in cross-section, demonstrating the tri-layer morphology and composition. Valvular interstitial cells ( VICs) are found inside the cusps, while valvular endothelial cells ( VECs) line the surfaces. The fibrosa ( aortic side) is rich in collagen fibers which run in a circumferential direction, while strands of radial elastin are contained in the ventricularis ( ventricular side). The proteoglycan-rich spongiosa acts as a Mechanical and Matrix Regulation of Valvular Fibrosis 27 tensile strength provides the majority of the valve’s strength and resistance against deformation while closed [12].

J Invest Dermatol 127:526–537. 42. Hinz B (2010) The myofibroblast: paradigm for a mechanically active cell. J Biomech 43:146–155. 43. Serini G, Bochaton-Piallat ML, Ropraz P, Geinoz A, Borsi L, Zardi L, Gabbiani G (1998) The fibronectin domain ED-A is crucial for myofibroblastic phenotype induction by transforming growth factor-beta1. J Cell Biol 142:873–881. 44. Biernacka A, Dobaczewski M, Frangogiannis NG (2011) TGF-beta signaling in fibrosis. Growth Factors 29:196–202. 45. Davis J, Burr AR, Davis GF, Birnbaumer L, Molkentin JD (2012) A TRPC6-dependent pathway for myofibroblast transdifferentiation and wound healing in vivo.

Download PDF sample

Rated 4.86 of 5 – based on 26 votes