Cardiac Mechanotransduction (Medical Intelligence Unit) by Matti Weckström

By Matti Weckström

This booklet provides a multidisciplinary method of cardiac mechanotransduction. The chapters depict the numerous faces of the subject, from membrane and ion channel point to mechanics, biochemical signaling and legislation through hormone platforms. Cardiac Mechanotransduction is of curiosity to uncomplicated existence sciences, like body structure, biochemistry and pharmacology, but additionally to clinicians operating with heart-related difficulties, comparable to cardiologists and internists.

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Am J Physiol Heart Circ Physiol 1993; 2 6 4 : H 9 6 0 - H 9 7 2 . 34. Sato R, Koumi S. Characterization of the stretch-activated chloride channel in isolated human atrial myocytes. J Membr Biol 1998; 163:67-76. 35. Kawakubo T , Naruse K, Matsubara T et al. Characterization of a newly found stretch-activated Kca,ATP channel in cultured chick ventricular myocytes. Am J Physiol Heart Circ Physiol 1999; 276':H1827-H1838. 36. Levin KR, Page E. Quantitative studies on plasmalemmal folds and caveolae of rabbit ventricular myocardial cells.

It has been suggested that the strong-binding crossbridge actually increases the affinity of TnC for Ca^^ through protein-protein interactions within the thin filament. ^^' The crossbridge plays a pivotal role in the length-tension relationship of cardiac muscle, and in a quest to understand this, the search has focused on factors that increase the probability of crossbridge formation. Aside from the degree of overlap of actin and myosin within the sarcomere, there are a number of factors that affect the probability of crossbridge formation.

Kentish J C , Wrzosek A. Changes in force and cytosolic Ca^^ concentration after length changes in isolated rat ventricular trabeculae. J Physiol (Lond) 1998; 506:431-444. 130. Alvarez BV, Perez N G , Ennis IL et al. Mechanisms underlying the increase in force and Ca^^ transient that follow stretch of cardiac muscle: A possible explanation of the Anrep effect. Circ Res 1999; 85:716-722. 131. Perez N G , de Hurtado M C , Cingolani H E . Reverse mode of the Na*-Ca^^ exchange after myocardial stretch: Underlying mechanism of the slow force response.

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