Cardiac Remodeling: Mechanisms and Treatment (Fundamental by Barry Greenberg

By Barry Greenberg

Exploring the reasons, mechanisms, and pathophysiology of cardiac home improvement, this reference bargains distinct descriptions of a number of the elements of the transforming method, in addition to new healing interventions and up to date and destiny clients for the remedy of cardiac home improvement.

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Extra resources for Cardiac Remodeling: Mechanisms and Treatment (Fundamental and Clinical Cardiology)

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B) A schema similar to (A) is demonstrated for 38MAPK (left panel) and JNK (right panel). Diastolic strain and systolic strain activated each pathway similarly. Key: --, strain; --, pacing; -`-, strain imposed during systolic phase; -&-, strain imposed during diastolic phase. Source: From Ref. 46. Figure 6 The rate of left ventricular myosin heavy chain synthesis (LV ks) is demonstrated for normal dogs (CONTROL), for acute severe pressure overload (POL), and for acute severe volume overload (VOL).

Throughout life, a ratio of left ventricular weight in grams to body weight in kilograms of about 4:1 is maintained in most mammalian species including man. 5 kg at birth to 80 kg in adulthood, there is an equivalent 20- to 25-fold increase in cardiac mass, almost all of which occurs through the hypertrophic process. This huge increase in cardiac mass during normal body growth is obviously normal and not associated with any deleterious consequences. Indeed the process is necessary for life. This point is necessary to emphasize that hypertrophy by itself is not necessarily pathologic.

The increased synthesis rate was in part accomplished by enhanced translation ef´Čüciency. Source: From Ref. 48. 20 Carabello Figure 9 Protein synthesis capacity is shown as total RNA, RNA/LV as measures of ribosomal number (A and B), and ribosomal synthesis rate (C). Capacity for protein synthesis increased following imposition of the pressure overload. Source: From Ref. 48. Ventricular Remodeling in Pressure vs. Volume Overload 21 Figure 10 Myosin heavy chain (MHC) synthesis (ks) and degradation (kd) rates for dogs with severe mitral regurgitation are expressed as %/day (A) and as mgs/day (B).

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