Cardiovascular Biomarkers: Pathophysiology and Disease by Robert H. Christenson PhD, Hassan M. E. Azzazy PhD, DABCC

By Robert H. Christenson PhD, Hassan M. E. Azzazy PhD, DABCC (auth.), David A. Morrow MD, MPH (eds.)

So quickly has the variety of cardiac assays on hand grown, after which more suitable, that present biomarkers not just diagnose heart problems, but in addition body remedy techniques. In Cardiovascular Biomarkers: Pathophysiology and illness administration, a individual panel of across the world famous opinion makers and specialists in medical and laboratory drugs synthesize the newest advancements within the use of cardiac biomarkers by means of the training doctor. The authors specialise in integrating biomarkers into the modern medical administration of sufferers with heart problems, emphasizing medical reviews, evidence-based diagnostic algorithms, and significant pathways for triage and remedy, each time on hand. in addition they remove darkness from the connections among particular biomarkers and the fundamental pathophysiology of heart problems, clarify the analytical houses of the assays correct to medical perform, and spotlight rising biomarkers and novel instructions for biomarker improvement. quite a few figures, illustrations, and tables make key proof and useful directions simply accessible.
State-of-the-art and hugely sensible, Cardiovascular Biomarkers: Pathophysiology and sickness administration makes transparent to contemporary busy cardiologists, emergency room physicians, and internists how many of the assays practice, which of them they need to order whilst comparing their sufferers, and the way the result of a biomarker assay can advisor their healing approaches.

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Ishikawa Y, Saffitz JE, Mealman RL, Grace AM, Roberts R. Reversible myocardial ischemic injury is not associated with increased creatine kinase activity in plasma. Clin Chem 1997;43:467–475. 37. Lee TH, Rouan GW, Weisberg MC, et al. Sensitivity of routine clinical criteria for diagnosing myocardial infarction within 24 hours of hospitalization. Ann Intern Med 1987;106:181–186. 38. Christenson RH, Vaidya H, Landt Y, et al. Standardization of creatine kinase-MB (CK-MB) mass assays: the use of recombinant CK-MB as a reference material.

Am Heart J 2002;144:981–986. Venge P, Lagerqvist B, Diderholm E, Lindahl B, Wallentin L. Clinical performance of three cardiac troponin assays in patients with unstable coronary artery disease (a FRISC II substudy). Am J Cardiol 2002; 89:1035–1041. Tate JR, Heathcote D, Koerbin G, et al. The harmonization of cardiac troponin I measurement is independent of sample time collection but is dependent on the source of calibrator. Clin Chim Acta 2002;324: 13–23. Tate JR, Heathcote D, Rayfield J, Hickman PE.

5. Lack of standardization for cTnI assays. Data are from the 2004 College of American Pathologists CAR-A Survey for Cardiac Markers (see ref. 20). Although each commercial assay (y-axis) demonstrates linearity for the two survey materials, they differ in the slope (“s”) of the line relative to the Dimension HM assay (arbitrarily selected as the predicate x-axis). *First-generation assay, no longer available. Table 2 Reasons for Lack of Concordance Among Cardiac Troponin Assays • Lack of standardization of the calibrating materials • Differences in the specificity of the antibodies used in the assays • Variability in the various forms of troponin found in blood and the reactivity of antibodies to these forms • Differences in the analytic performance of assays with particular reference to analytic sensitivity and assay imprecision determine whether they had acceptably low matrix-associated variations (“commutability”) when diluted in human serum or a suitable diluent selected by the manufacturer, and whether they could be used as calibrators to produce identical results for different cTnI assays (“harmonization”).

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