Coronary Angiogenesis by E. Edward Bittar (Eds.)

By E. Edward Bittar (Eds.)

This quantity surveys the growth that has been made within the examine of coronary angiogenesis and gives the reader with a basic assurance of the advances within the middle wisdom within the box. it really is transparent that as we achieve a deeper realizing of mechanisms underlying stimulation (and inhibition) of coronary angiogenisis, it will probably turn into attainable to strengthen novel remedies for expanding the expansion and formation of collateral vessels within the ischemic middle. even if study within the area of angiogenesis is progressively drawing close its golden age, the examine of coronary angiogenesis continues to be in its infancy.

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Because of the proximity of the lesions to the macula, laser photocoagulationor surgical therapy are of very limited value. , 1996). These findings suggest a role for VEGF in the progressionof AMD-related choroidal neovascularization,raising the possibility that treatment with monoclonal antibodies or other VEGF inhibitors may be beneficial. , 1994). , 1994). , 1994). Increased vascularity and permeabilityare characteristicof psoriasis. , 1995b). Angiogenesis plays a role in the pathogenesis of endometriosis, a condition characterized by ectopic endometrium implants in the peritoneal cavity.

19%). Inhibition of vascular endothelial growth factor prevents retinal ischemia-associated iris neovascularization in a nonhuman primate. Arch. Ophthalmol. 114, 66-7 1. , Thieme. , Ferrara, N. L. (1994). Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N. Engl. J. Med. 331, 1480-1487. L. E. (1995). Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins.

If this is true, then anti-VEGF antibodies or other inhibitorsof VEGF might be of therapeutic value for a variety of malignancies and other disorders, used alone or in combination with other agents. , submitted)and is being tested in humans as a treatment for solid tumors. In conclusion, in spite of the many factors potentially involved in angiogenesis, one specific factor, VEGF, appears to play a primary role in a variety of physiological and pathological conditions. (1994). Increased vascular endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathy.

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