Coronary atherosclerosis: current management and treatment by Chourmouzios Arampatzis, Eugene P McFadden, Lampros K

By Chourmouzios Arampatzis, Eugene P McFadden, Lampros K Michalis, Renu Virmani, Patrick W. Serruys

Coronary Atherosclerosis: present administration and remedy addresses the best reason behind dying around the globe - coronary artery affliction. Atherosclerosis has a vast diversity of disorder manifestations looking on the measure of the stenosis, and the practical prestige of the coronary plaque and is a affliction cardiologists deal with each day. incidence of coronary artery sickness is expanding as a better variety of humans live Read more...

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World Health Organization (WHO)/International Society of Hypertension (ISH) statement on management of hypertension. J Hypertens 2003; 21: 1983–92. 16. Chobanian AV, Bakris GL, Black HR, et al. The seventh report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure: the JNC 7 report. JAMA 2003; 289: 2560–72. 17. Neaton JD, Blackburn H, Jacobs D, et al. Serum cholesterol level and mortality findings for men screened in the Multiple Risk Factor 18.

Complements genomics by providing a more accurate evaluation of specific markers of a biological process (12). Along the same lines, proteomics can contribute to the identification of target molecules that are involved in a particular pathologic process (13). Most importantly, proteomics can also analyze posttranslational changes in proteins, thereby providing more accurate information on the biological process. An example that is relevant to atherosclerosis is post-translational modification leading to the formation of advanced glycation end-products (14).

1. The most commonly used technique is mass spectometry, where proteins from a particular sample are metabolized into small peptides, allowing for quantitative and qualitative analysis by high-performance liquid chromatography (HPLC) (16,17). 3 illustrate the different steps involved in the identification of new biomarkers by proteomic analysis. Despite the great potential of mass spectrometry in proteomics, the application of this technique for cardiovascular risk prediction in clinical trials is still ongoing and requires more investigation.

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