By RC Andrew Thompson, Anthony Armson and Una M. Ryan (Eds.)
Within the rather brief interval for the reason that Cryptosporidium was once acknowledged as a human pathogen, and that it may be transmitted in water in addition to without delay among animals and folks, it's been the topic of extreme investigations. Its prestige as an opportunistic pathogen, in particular in AIDS sufferers, and the inability of potent anti-cryptosporidial medicinal drugs have served to emphasize the general public future health significance of this organism. This has to a point overshadowed the truth that Cryptosporidium is additionally a big pathogen of household animals and natural world.
In contemporary years, the applying of molecular biology and tradition innovations have had an important influence on our figuring out of the aetiological brokers of cryptosporidial infections and our skill to review the causative brokers within the laboratory. accordingly, a wealth of knowledge and novel facts has been produced over the last 3-4 years, quite within the components of taxonomy, biology, pathogenesis, epidemiology - rather zoonotic and water borne transmission, and treatment.
It is therefore very well timed to collect during this booklet the foreign study neighborhood concerned to check the key advances in study and establish the $64000 study priorities for the longer term, hence permitting as extensive an viewers as attainable to profit from and percentage during this entire examine Cryptosporidium and cryptosporidiosis.
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Additional info for Cryptosporidium. From Molecules to Disease
Meligro, C. and Rubin, C , 1976. Overwhelming watery diarrhea associated with a Cryptosporidium in an immunosuppressed patient. , 70: 1156-1160. A. , 1999. Variation in Cryptosporidium: towards a taxonomic revision of the genus. Int. J. , 29: 1733-1751. , Moore, A. , 2000a. Molecular characterization of Cryptosporidium isolates obtained from human immunodeficiency vimsinfected individuals living in Switzerland, Kenya and the United States. J. Clin. , 38: 1180-1183. , Lai, A. , 2000b. Detection of Cryptosporidium parvum "human" genotype in a dugong (Dugong dugon).
In contrast, the infected host may benefit by bathing the gut in IgA, complement and other defensive weaponry, as well as physically eliminating cells which contain developing parasites, thus limiting the spread to contiguous epithelium. It is interesting, then, that while a number of C. parvum isolates can replicate and produce oocysts in a variety of mammals, not all mammalian species develop the same symptoms, or indeed in some cases, any symptoms at all. This varied outcome in different host species has made finding a suitable surrogate for human infection problematic.
23: 487-509. , 1912. Cryptosporidium parvum (sp. ), a coccidium found in the small intestine of the common mouse. Arch. , 26: 394-412. , Campbell, I. W. 1980. Cryptosporidium: evidence for a single species genus. Infect. , 30: 884-886. , 1990. Cryptosporidiosis in humans (Homo sapiens). P. A. Speer and R. ), Cryptosporidiosis of Man and Animals. CRC Press, Boca Raton, Florida, pp. 60-82. S. , 1989. Cryptosporidium spp. In wild and captive reptiles. J. Wildl. , 25: 20-30. G. , 1971. Cryptosporidium wrairi sp.