By Xiaoling Li
The objective of each drug supply procedure is to convey the fitting quantity of a drug at a pre-programmed price to the specified position with a view to in achieving the drug point invaluable for the remedy. an important advisor for biomedical engineers and pharmaceutical designers, this source combines physicochemical ideas with physiological methods to facilitate the layout of platforms that may bring medicine on the time and position it truly is so much wanted.
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Extra info for Design of Controlled Release Drug Delivery Systems (McGraw-Hill Chemical Engineering)
In the “distributive phase,” the decrease in the Cp kinetic profile is not due only to distribution but also to both distribution and elimination—hence the sharp slope. In the “elimination” or “postdistributive” phases, the central compartment is at steady state with the tissue compartment, and the Cp kinetic profile is primarily due to elimination of drug (which includes drug being transferred from the tissues into the central compartment). There are multiple volume terms associated with this model: V1 and V2 (volumes of compartments 1 and 2), Vd,ss (volume at steady state), Vd,area or Vd·β, and Vd,extrap.
11. The differential Zero-order input and one-compartment disposition (I0D1). 11 Zero-order input and one-compartment disposition box diagram. Pharmacokinetics and Pharmacodynamics in Controlled Delivery System Design 19 equation (Eq. 22) describes an I0D1 model, and its integrated form is shown in Eqs. 24) where k0 is the zero-order input rate constant (units of amount per time), K is the first-order elimination rate constant (units of 1/time), Vd is the volume of distribution, and Cp is the drug plasma concentration.
The colon is divided into five regions: cecum, ascending colon, transverse colon, descending colon, and sigmoid colon (see Fig. 1). Histologically, colonic mucosa resembles small intestinal mucosa, the absence of villi being the major difference (Fig. 3). 1). However, the colonic residence time is longer than that for the small intestine, providing extended periods of time for the slow absorption of drugs. , and Bacteroides spp.