By Gustavo Maroni
Univ. of North Carolina, Chapel Hill. Textbook for undergraduates and graduates acquainted with easy genetics. Assumes wisdom of meiosis and Mendelian genetics. subject matters succeed: How can we determine trait is hereditary? and the way can the houses of a trait be defined via the underlying molecular motives? End-of-chapter routines are integrated. Softcover.
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Extra resources for Molecular and Genetic Analysis of Human Traits
What is the prior probability that they will have an albino child? What is the prior probability that individuals 111-7 and 111-8 will have an affected child? (C) Does the phenotype of the offspring that these two couples have had affect the probability that an unborn child will be affected? (D) What is the probability that 111-4 and 111-5 will have an albino child? 1-5. X-linked recessive inheritance, such as colorblindness, can be demonstrated by verifjmg that, among the offspring of carrier mothers and normal fathers, none of the daughters and half of the sons show the trait.
Hams H. (1975) The principles of human biochemical genetics. New York American Elsevier. Wexler N, et al. (1987) Homozygotes for Huntington’s disease. Nature 326:194-197. Haws DV, and McKusick V (1969) Farabee’s brachydactylous kindred revisited. Bull Johns Hopkins Hosp 113:20-30. White R, Leppert M, Bishop DT, Barker D, Berkowitz J, Brown C, Callahan P, Holm T, and Jerominski L. (1985) Construction of linkage maps with DNA markers for human chromosomes. Nature 3131101-105. Lagestrdm M, Dahl N, Iselius L, Backman B, and Pettersson U.
In this chapter we will also explore 1) how it is possible to test whether a given trait is hereditary, and 2) if a trait is hereditary, how scientists go about establishing 31 Chapter 2 Hereditary Traits That Do Not Show a Simple Mendelian Pattern the mode of inheritance and pinpointing the gene(s) responsible. In Chapters 3 and 4 we will see how the genetic approaches studied in these first two chapters are brought together with molecular methods to obtain a global understanding of human inheritance in the Human Genome Project.