By Robert Lanza
The chance that tissue engineering presents for drugs is remarkable. within the usa by myself, over half-a-trillion cash are spent every year to deal with sufferers who are suffering from tissue loss or disorder. even supposing a variety of books and studies were written on tissue engineering, none has been as accomplished in its defining of the sector. Principles of Tissue Engineering combines in a single quantity the necessities for a basic figuring out of tissue development and improvement, the instruments and theoretical details had to layout tissues and organs, in addition to a presentation of functions of tissue engineering to ailments affecting particular organ platforms. the 1st version of the ebook, released in 1997, is the yes reference within the box. because that point, despite the fact that, the self-discipline has grown drastically, and few specialists might were capable of are expecting the explosion in our wisdom of gene expression, cellphone development and differentiation, the diversity of stem cells, new polymers and fabrics which are now to be had, or perhaps the profitable advent of the 1st tissue-engineered items into undefined. there has been a necessity for a brand new variation, and this want has been met with a product that defines and captures the feel of pleasure, knowing and anticipation that has from the evolution of this attention-grabbing and demanding box.
* presents mammoth, specified research of study on all the significant structures of the human physique, e.g., epidermis, muscle, cardiovascular, hematopoietic, and nerves
* necessary to a person operating within the field
* Educates and directs either the beginner and complicated researcher
* presents titanic, specific research of study with the entire significant platforms of the human physique, e.g. epidermis, muscle, cardiovascular, hematopoietic, and nerves
* Has new chapters written through leaders within the most up-to-date components of study, akin to fetal tissue engineering and the common cell
* thought of the definitive reference within the field
* record of individuals reads like a "who's who" of tissue engineering, and contains Robert Langer, Joseph Vacanti, Charles Vacanti, Robert Nerem, A. Hari Reddi, Gail Naughton, George Whitesides, Doug Lauffenburger, and Eugene Bell, between others
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Additional info for Principles of Tissue Engineering, Second Edition
Bell, E. (1995). Strategy for the selection of scaffolds for tissue engineering. Tissue Eng. 1, 163 –179. , and Merrill, C. (1979). Production of a tissue-like structure by contraction of collagen lattices by fibroblasts of different proliferative potential in vitro. Proc. Natl. Acad. Sci. A. 76, 1274 –1278. , Ehrlich, H. , and Nakatsuji, T. (1981). Living tissue formed in vitro and accepted as skin equivalent tissue in vitro. Science 211, 1052–1054. , and Coon, H. (1984). Reconstitution of a thyroid gland equivalent from cells and matrix materials.
Much is already known about stem cells and cell lineages in the bone marrow and blood. Studies suggest that progenitor cells for many differentiated tissues exist within the marrow and blood, and may very well be ubiquitous. Our knowledge of the existence and behavior of such cells in various mesenchymal tissues (muscle, bone, and cartilage), endodermally derived tissues (intestine and liver), or ectodermally derived tissues (nerves, pancreas, and skin) expands on a daily basis. A new area of stem cell biology involving embryonic stem cells holds promise for tissue engineering.
Obviously, this is a significant advance, but for truly “normal” skin to be engineered, all of the cellular elements should be contained, so that the specialized appendages can be generated as well. These “simple” composites will indeed prove to be quite complex and require intricate designs. Thicker structures with relatively high ratios of surface area to mass, such as liver, kidney, heart, breast, or central nervous system, will offer other engineering challenges. Currently, studies for developing and designing materials in three-dimensional space are being developed utilizing both naturally occurring and synthetic molecules.