By Peter Spector
Within the fast moving international of scientific education, scholars are frequently inundated with the
what of electrophysiology with no the
why. This new textual content is designed to inform the tale of electrophysiology in order that the probably disparate myriad observations of medical perform come into concentration as a cohesive and predictable complete.
- Presents a different, conceptually-guided method of knowing the move of electric present throughout the center, the effect of varied sickness states and the optimistic impact of treatment
- Reviews electrophysiologic rules and the analytic instruments which, whilst mixed with an organization seize of EP mechanisms, enable the reader to imagine via any situation
- Presents the math precious for the perform of cardiac electrophysiology in an obtainable and comprehensible manner
- Contains accompanying movies, together with desktop simulations displaying the movement of electric present throughout the center, which support clarify and visualise thoughts mentioned within the text
- Includes worthwhile bankruptcy summaries and entire colour illustrations reduction comprehension
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Within the fast-paced international of scientific education, scholars are usually inundated with the what of electrophysiology with out the why. This new textual content is designed to inform the tale of electrophysiology in order that the possible disparate myriad observations of medical perform come into concentration as a cohesive and predictable complete.
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Extra info for Understanding Cardiac Electrophysiology: A Conceptually Guided Approach
Peter Spector. © 2016 John Wiley & Sons, Inc. Published 2016 by John Wiley & Sons, Inc. 1 Source and sink. Source is the current available to depolarize unexcited cells. Sink is the net current required to depolarize unexcited cells to threshold. 2 Sink size varies. If the amount of source current is unchanged while the size of the sink increases, the membrane will depolarize less. 3 Intercellular coupling increases sink size. As cells are electrically connected, the source current is distributed to a greater number of cells.
Summary • Action potential phases: rest (4), depolarization (0), early repolarization (1), plateau (2), repolarization (3). • Phase 4: At rest only IK1 is open. • Phase 0: When Vm reaches INa activation threshold, sodium channels open. Na+ enters the cell (down its voltage and concentration gradient). Vm depolarizes rapidly. K+ channels close. The threshold for INa inactivation is essentially the same as the threshold for activation. Because inactivation kinetics are much slower than activation kinetics, there is a transient inward Na+ current.
Wave break, in this case, creates the circuit and is the unidirectional block. The path length is the inner circumference of rotation. The initiation of a rotor requires wave break (which creates a free wave end); wave break occurs due to structural or functional block. Heterogeneity of APD (and hence refractoriness) enhances the likelihood of wave break. Rapid firing (due to pacing or spontaneous ectopy) sets the stage for one wave to collide (in some places but not others) with the tail of the prior wave, initiating wave break and rotation.